Starting a business in the United States can open doors for massive opportunity and success. Along the way, however, businesses will encounter a number of legal and regulatory hurdles. This “Guide to Starting Business in the U.S.” reflects the incalculable number of personal, legislative, health and safety and business changes that have resulted from the COVID-19 pandemic. While many of the fundamental components of starting a business in the United States have not changed (e.g., choice of entity, entity formation and registering IP), a multitude of policies, protocols and legislative changes have impacted various practical, financial and risk considerations international businesses must consider when starting a business in the U.S. (e.g., immigration, tax, employment, privacy and security and economic incentives for certain industries).